Hs 27

CAS NO.：1562024-11-6
Empirical Formula: C52H60N6O12S
Molecular Weight: 993.13
MDL number: MFCD32173434
Update Date: 2026-01-05 15:21:26

What is Hs 27?

Biological Activity

HS-27, a fluorescent Hsp90 inhibitor, detects Hsp90 expression on the surface of intact tissue specimens. It consists of the core elements of SNX-5422, an Hsp90 inhibitor linked via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC) that binds to peripherally expressed Hsp90 combine.

in vitro

HS-27 labels all receptor subtypes of breast cancer, but not normal cells, and specifically binds to Hsp90 expressed on the surface of breast cancer cells before being internalized.

Properties of Hs 27

Boiling point:	1095.1±75.0 °C(Predicted)
Density	1.39±0.1 g/cm3(Predicted)
storage temp.	-196°C
solubility	DMSO: 125 mg/mL (125.86 mM)
pka	9.33±0.20(Predicted)
form	Solid
color	Yellow to orange

Safety information for Hs 27

Computed Descriptors for Hs 27

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