holomycin
- CAS NO.：488-04-0
- Empirical Formula: C7H6N2O2S2
- Molecular Weight: 214.26
- MDL number: MFCD01670588
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-16 07:06:08
What is holomycin?
The Uses of holomycin
Holomycin-d3 is the isotope labelled analog of Holomycin (H458490); a member of the pyrrothine class of antibiotics that displays broad-spectrum antibacterial activity.
What are the applications of Application
Holomycin is a member of the pyrrothine class of antibiotics and displays broad-spectrum antibacterial activity
Definition
ChEBI: Holomycin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties. It has a role as a chelator, an antineoplastic agent, an EC 2.7.7.6 (RNA polymerase) inhibitor, an antibacterial agent, a marine metabolite and a bacterial metabolite. It is a dithiolopyrrolone antibiotic and a member of acetamides.
Synthesis Reference(s)
Journal of the American Chemical Society, 86, p. 5654, 1964 DOI: 10.1021/ja01078a049
Properties of holomycin
| Melting point: | 268 °C (decomp) |
| Boiling point: | 532.1±50.0 °C(Predicted) |
| Density | 1.63±0.1 g/cm3(Predicted) |
| solubility | DMSO, Methanol (Heated) |
| form | Solid |
| pka | 9.33±0.40(Predicted) |
| color | Brown-Orange |
Safety information for holomycin
Computed Descriptors for holomycin
New Products
5-bromo-4-fluoro-2-nitrobenzaldehyde (R)-(-)-2-Amino-1-propanol Cyclobutanone Fmoc-OSu 1-(2-Chloroethyl)pyrrolidine Hydrochloride 2-Amino-2-(4-methylphenyl)acetic acid β-Bromostyrene Ethyl 3-phenylpropanoate Phenethyl cinnamate Dipropyl disulfide 4 pentyn 1 ol N-Vinylformamide Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
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