HO-PEG5-CH2COOtBu
- CAS NO.：52026-48-9
- Empirical Formula: C12H24O8
- Molecular Weight: 296.31
- MDL number: MFCD31656910
- Update Date: 2026-05-28 04:55:48
What is HO-PEG5-CH2COOtBu?
Biological Activity
HO-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Properties of HO-PEG5-CH2COOtBu
| Boiling point: | 444.5±40.0 °C(Predicted) |
| Density | 1.182±0.06 g/cm3(Predicted) |
| pka | 3.39±0.10(Predicted) |
Safety information for HO-PEG5-CH2COOtBu
Computed Descriptors for HO-PEG5-CH2COOtBu
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