HO-PEG5-CH2COOtBu
- CAS NO.：52026-48-9
- Empirical Formula: C12H24O8
- Molecular Weight: 296.31
- MDL number: MFCD31656910
- Update Date: 2026-04-21 10:31:43
What is HO-PEG5-CH2COOtBu?
Biological Activity
HO-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Properties of HO-PEG5-CH2COOtBu
| Boiling point: | 444.5±40.0 °C(Predicted) |
| Density | 1.182±0.06 g/cm3(Predicted) |
| pka | 3.39±0.10(Predicted) |
Safety information for HO-PEG5-CH2COOtBu
Computed Descriptors for HO-PEG5-CH2COOtBu
New Products
Hendecanoic acid 2-Amino-5-cyanopyridine 2-Bromo-5-cyanopyridine DL-3-Amino-3-(2-methoxyphenyl)propionic acid 3-Hydroxypropionitrile 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile 4,4-Diethoxybutanenitrile 3′-Hydroxyacetophenone 5-fluoro-1,3-benzodioxole Tetracaine Hydrochloride Ep Grade 2,2,2-Trichloroethyl chloroformate 2-Bromo-6-fluoroaniline 2-Amino-4-phenyl-thiazole 4-Chloro-2-methyl quinoline 2-(Chloromethyl) quinazolin-4(3H)-one 5-Phenyl-[1,3,4]-thiadiazol-2-amine 2-Chloro-6-nitro benzothiazole 2-Aminobenzo[d]thiazol-4-ol 1-(4-Aminopiperidin-1-yl)-3,3,3-trifluoropropan-1-one 5-chloro-2-(4-methoxybenzyl)-4-(trifluoromethyl)pyridazin-3(2H)-one 3-cyanocyclohexane-1-carboxylic acid N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methacrylamide 2-(difluoromethyl)-4H-chromen-4-oneRelated products of tetrahydrofuran
You may like
-
103095-63-2 DL-3-Amino-3-(2-methoxyphenyl)propionic acid 98+View Details
103095-63-2 -
3-Hydroxypropionitrile 98+View Details
109-78-4 -
103095-63-2 DL-3-Amino-3-(2-methoxyphenyl)propionic acid 98+View Details
103095-63-2 -
117391-48-7 98+View Details
117391-48-7 -
3-Hydroxypropionitrile 98+View Details
109-78-4 -
103095-63-2 DL-3-Amino-3-(2-methoxyphenyl)propionic acid 98+View Details
103095-63-2 -
117391-48-7 98+View Details
117391-48-7 -
3-Hydroxypropionitrile 98+View Details
109-78-4
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.