HEXAMETHONIUM CHLORIDE
Synonym(s):Hexamethonium dichloride;N,N,N,N′,N′,N′-Hexamethyl-1,6-hexanediaminium dichloride;N,N,N,N′,N′,N′-Hexamethylhexamethylenediammonium dichloride
- CAS NO.：60-25-3
- Empirical Formula: C12H30Cl2N2
- Molecular Weight: 273.29
- MDL number: MFCD00031563
- EINECS: 200-465-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-12 15:35:02
What is HEXAMETHONIUM CHLORIDE?
Chemical properties
White, crystalline, hygroscopic powder; faint odor. Very soluble in water; soluble in alcohol, methanol, and n-propanol; insoluble in chloroform and ether. Available commercially as unhydrated form or as dihydrate.
The Uses of HEXAMETHONIUM CHLORIDE
Hexamethonium Chloride is a ganglionic nicotinic receptor blocker.
The Uses of HEXAMETHONIUM CHLORIDE
Medicine (antihypertensive).
The Uses of HEXAMETHONIUM CHLORIDE
Hexamethonium chloride has been used to block the responses of nicotinic receptors towards it agonists. It has also been used to study the mechanosensitivity of viscerofugal neurons.
What are the applications of Application
Hexamethonium chloride is A preferential nicotinic receptor blocker.
General Description
Nicotinic acetylcholine receptor (nAChR) forms a ligand-gated ion channel made up of four different subunits. Each subunit contains an extracellular amino-terminal domain (hydrophilic) and carboxylic terminal domain and four transmembrane domains. nAChR is an allosteric and transmembrane protein localized to the neuromuscular junction.
Biochem/physiol Actions
Hexamethonium chloride preferentially blocks nicotinic receptors at autonomic ganglia, crosses blood-brain barrier only at high doses. Nicotinic acetylcholine receptor (nAChR) is responsible for cognitive functions. Blocking this receptor results in cognitive impairment. nAChR antagonist is used to study the effect of loss of receptor function. Hexamethonium has a peripheral action over blocking the nAChR.
Properties of HEXAMETHONIUM CHLORIDE
| Melting point: | 292°C(dec.)(lit.) |
| Boiling point: | 423.36°C (rough estimate) |
| Density | 1.0558 (rough estimate) |
| refractive index | 1.6400 (estimate) |
| solubility | H2O: soluble |
| form | solid (hygroscopic) |
| color | white |
| Water Solubility | almost transparency |
| BRN | 3714806 |
| CAS DataBase Reference | 60-25-3 |
| EPA Substance Registry System | 1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-, dichloride (60-25-3) |
Safety information for HEXAMETHONIUM CHLORIDE
Computed Descriptors for HEXAMETHONIUM CHLORIDE
New Products
2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 2-fluoro-4-iodoaniline 4-Iodo-3,5-dimethylbenzonitrile Atorvastatin amide impurity/Atorvastatin EP Impurity F(Calcium Salt) Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-Fluoro-4-nitrotoluene 1-(2-amino-5-hydroxy phenyl)propan-1-one (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 3-(Dimethylamino)benzoic acid 2-Amino-5-chloropyridine 4-(Methylamino)-3-nitrobenzoic Acid 5-Chloro-2-Nitroaniline 3,5-dibenzyloxy Acetophenone 2,4-Diamino-6-hydroxypyrimidine 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy BenzylcyanideRelated products of tetrahydrofuran
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