Hexahydrocurcumin

Synonym(s):(RS)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone

CAS NO.：36062-05-2
Empirical Formula: C21H26O6
Molecular Weight: 374.43
MDL number: MFCD18783096
SAFETY DATA SHEET (SDS)
Update Date: 2026-11-04 16:50:45

What is Hexahydrocurcumin?

Description

Hexahydrocurcumin is a natural product and glucuronide metabolite of curcumin that has anti-inflammatory, antioxidant, and anticancer properties. It reduces prostaglandin E₂ (PGE₂) production stimulated by phorbol 12-myristate 13-acetate (PMA; ) by 37% in human colonic epithelial cells when used at a concentration of 20 μM. Hexahydrocurcumin (3.125-25 μM) inhibits overproduction of nitric oxide induced by LPS in RAW 264.7 macrophage cells in a concentration-dependent manner. It does not affect LPS-induced cytokine release but inhibits LPS-induced iNOS and COX-2 upregulation and NF-κB activation when used at a concentration of 50 μM. Hexahydrocurcumin prevents the formation of aberrant crypt foci in a dimethylhydrazine rat model of colon cancer and potentiates the effect of 5-fluorouracil .

The Uses of Hexahydrocurcumin

Hexahydrocurcumin is an intermediate in the synthesis of Gingerenone A (G387500) which is an antifungal and antiparasitic diarylheptenone that is isolated from Zingiber officinale (more commonly known as ginger), a medicinal plant that is used to treat inflammation and musculoskeletal disorders.

Definition

ChEBI: Hexahydrocurcumin is a diarylheptanoid.

Properties of Hexahydrocurcumin

Melting point:	80-82℃
Boiling point:	622.6±55.0 °C(Predicted)
Density	1.226
Flash point:	218℃
storage temp.	2-8°C
solubility	Chloroform (Sparingly), Ethyl Acetate (Slightly), DCM, DMSO
form	neat
pka	10.02±0.20(Predicted)
form	Solid
color	Pale Yellow
BRN	2486876

Safety information for Hexahydrocurcumin

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.