FLLL31

Synonym(s):(E,E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione;Tetramethylcurcumin

CAS NO.：52328-97-9
Empirical Formula: C25H28O6
Molecular Weight: 424.49
MDL number: MFCD19443859
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-28 20:32:43

What is FLLL31?

Biological Activity

Tetramethylcurcumin (FLLL31) is derived from curcumin and specifically inhibits phosphorylation of STAT3 by selectively binding to Janus kinase 2 and the STAT3 Src homology 2 domain. Tetramethylcurcumin has anti-inflammatory and anticancer effects.

in vitro

Tetramethylcurcumin (FLLL31; 2.5 and 5 μM; for 24 hours) downregulas STAT3 phosphorylation and DNA-binding activity in MDA-MB-231 breast and PANC-1 pancreatic cancer cells.
Tetramethylcurcumin inhibits cell viability , cell invasion. Tetramethylcurcumin is an effective inhibitor of STAT3 phosphorylation, DNA-binding activity, and transactivation in vitro, leading to the impediment of multiple oncogenic processes and the induction of apoptosis in pancreatic and breast cancer cell lines.

Properties of FLLL31

Boiling point:	594.5±50.0 °C(Predicted)
Density	1.140±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ≥10mg/mL
form	powder
color	yellow

Safety information for FLLL31

Signal word	Warning
Pictogram(s)	Environment GHS09
GHS Hazard Statements	H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment. P501:Dispose of contents/container to..…