Hexahydro-4-methylphthalic anhydride

Description

Methylhexahydrophthalic anhydride (MHHP A) is an epoxy hardener, irritant to skin and mucus membranes. It is included in non-diglycidyl-ether-of-bisphenol- A epoxy resins. It can induce both allergic contact dermatitis and immunologic contact urticaria. MHHP A is structurally close to methyltetrahydrophthalic anhydride (MTHP A), which can also cause sensitization.

Chemical properties

Hexahydro-4-methylphthalic anhydride has a melting point of 29 °C, so it is a liquid at room temperature. It has a boiling point of 120 °C and at 25 °C its density is 1.162 g/mL.

The Uses of Hexahydro-4-methylphthalic anhydride

Hexahydro-4-methylphthalic anhydride, mixture of?cis?and?trans may be used as an analytical standard for the determination of the analyte in human biological samples by gas chromatography-mass spectrometry (GC-MS).

General Description

Methylhexahydrophthalic anhydride, a congener of phthalic anhydride, is utilized in the production of plastics, paints, and electronic components. It can potentially result in allergenic effects on humans upon exposure and cause immunological reactions.

Flammability and Explosibility

Non flammable

Contact allergens

Methylhexahydrophthalic anhydride is an epoxy hardener, irritant to skin and mucous membranes. It is included in nondiglycidyl-ether-of-bisphenol-A epoxy resins. It can induce both allergic contact dermatitis and immunologic contact urticaria. It is structurally close to methyltetrahydrophthalic anhydride, which can also cause sensitization.

Synthesis

5-methyl-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione could used as a starting material to synthesize Hexahydro-4-methylphthalic anhydride. The byproducts include 5-methylisobenzofuran-1,3-dione, 5-methyl-4,5,6,7-tetrahydroisobenzofuran-1,3-dione, and 6-methyl-3a,4,5,7a-tetrahydroisobenzofuran-1,3-dione.