HEXAFLUOROACETYLACETONE

Synonym(s):1,1,1,5,5,5-Hexafluoro-2,4-pentanedione;1,1,1,5,5,5-Hexafluoroacetylacetone

CAS NO.：1522-22-1
Empirical Formula: C5H2F6O2
Molecular Weight: 208.06
MDL number: MFCD00000426
EINECS: 216-191-0
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:27:03

What is HEXAFLUOROACETYLACETONE?

Chemical properties

clear colorless to slightly yellow liquid

The Uses of HEXAFLUOROACETYLACETONE

1,1,1,5,5,5-Hexafluoro-2,4-pentanedione acts as a chelating ligand. It is used as liquid crystal intermediate.

General Description

Hexafluoroacetylacetone forms metal-chelate complexes with Cu(II), Ni(II), Co(II), Nd(III), Rh(III), Fe(III) and Cr(III). Hexafluoroacetylacetone on hydration yields 1,1,1,5,5,5-hexafluoropentane-2,2,4,4-tetraol.

Purification Methods

It forms a dihydrate which has no UV spectrum compared with max (CHCl3) 273nm ( 7,800) for the anhydrous ketone. The dihydrate decomposes at ~90o. The hydrate (10g) plus anhydous CaSO4 (Drierite, 30g) are heated and distilled, the distillate is treated with more CaSO4 and redistilled. When the distillate is treated with aqueous NaOH and heated, the dihydrate crystallises on cooling. The Cu complex has m 135o (after sublimation). [Gilman et al. J Am Chem Soc 78 2790 1956, Belford et al. J Inorg Nucl Chem 2 11 1956, Beilstein 1 IV 3681.]

Properties of HEXAFLUOROACETYLACETONE

Boiling point:	70-71 °C (lit.)
Density	1.47 g/mL at 25 °C (lit.)
refractive index	n20/D 1.332(lit.)
Flash point:	32 °C
storage temp.	Inert atmosphere,Room Temperature
form	Liquid
pka	4.30±0.10(Predicted)
Specific Gravity	1.470
color	Clear colorless to slightly yellow
Water Solubility	Not miscible in water.
Sensitive	Hygroscopic
BRN	1790138
CAS DataBase Reference	1522-22-1(CAS DataBase Reference)
EPA Substance Registry System	2,4-Pentanedione, 1,1,1,5,5,5-hexafluoro- (1522-22-1)

Safety information for HEXAFLUOROACETYLACETONE

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H314:Skin corrosion/irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.