Hesperidin methylchalcone

Synonym(s):(E)-1-[4-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-?-D-glucopyranosyl]oxy]-2-hydroxy-6-methoxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-2-propen-1-one

CAS NO.：24292-52-2
Empirical Formula: C29H36O15
Molecular Weight: 624.59
MDL number: MFCD00010438
EINECS: 246-128-2
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-23 08:01:08

What is Hesperidin methylchalcone?

Description

Hesperidin methylchalcone (HMC) is a flavonoid with potent free radical quenching properties and is a highly complex compound typically found in bright-colored plants and flowers. In skincare, it is primarily used as an antioxidant, with noted effects on circulation for reducing dark circles and melanin synthesis. Hesperidin, in its raw form, has poor absorption. Hence, it is modified into HMC for better stability and skin compatibility.

The Uses of Hesperidin methylchalcone

Hesperidin Methylchalcone is a flavonoid agent used in the treatment of venous insufficiency.

The Uses of Hesperidin methylchalcone

hesperidin methyl chalcone is a citrus bioflavonoid. extracted from the peel of sweet oranges, it has anti-oxidant properties. It is used in eye care preparations for reducing the appearance of dark circles.

Benefits

Hesperidin MethylChalcone (HMC) is a very interesting antioxidant as it is one of the rare Barrier Repair Antioxidants. It is able to increase Filaggrin and B-glucocerebrosidase which are essential for Ceramide production. The other notable use for HMC is its ability to reduce capillary permeability for dark cicles around the eyes.
The benefits of HMC include: Anti-dark Circles, Antioxidant, Barrier Repair, and Anti-aging.

Properties of Hesperidin methylchalcone

Melting point:	120 °C (dec.)(lit.)
Boiling point:	583.81°C (rough estimate)
alpha	-71 º (c=1 in ethanol)
Density	1.3090 (rough estimate)
refractive index	1.5940 (estimate)
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	6.71±0.40(Predicted)
color	Yellow
optical activity	[α]20/D 71°, c = 1 in ethanol
CAS DataBase Reference	24292-52-2(CAS DataBase Reference)
EPA Substance Registry System	Hesperidin methylchalcone (24292-52-2)

Safety information for Hesperidin methylchalcone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.