Hesperidin methylchalcone
Synonym(s):(E)-1-[4-[[6-O-(6-Deoxy-α-L -mannopyranosyl)-?-D -glucopyranosyl]oxy]-2-hydroxy-6-methoxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)-2-propen-1-one
- CAS NO.：24292-52-2
- Empirical Formula: C29H36O15
- Molecular Weight: 624.59
- MDL number: MFCD00010438
- EINECS: 246-128-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 04:16:24
What is Hesperidin methylchalcone?
Description
Hesperidin methylchalcone (HMC) is a flavonoid with potent free radical quenching properties and is a highly complex compound typically found in bright-colored plants and flowers. In skincare, it is primarily used as an antioxidant, with noted effects on circulation for reducing dark circles and melanin synthesis. Hesperidin, in its raw form, has poor absorption. Hence, it is modified into HMC for better stability and skin compatibility.
The Uses of Hesperidin methylchalcone
Hesperidin Methylchalcone is a flavonoid agent used in the treatment of venous insufficiency.
The Uses of Hesperidin methylchalcone
hesperidin methyl chalcone is a citrus bioflavonoid. extracted from the peel of sweet oranges, it has anti-oxidant properties. It is used in eye care preparations for reducing the appearance of dark circles.
Benefits
Hesperidin MethylChalcone (HMC) is a very interesting antioxidant as it is one of the rare Barrier Repair Antioxidants. It is able to increase Filaggrin and B-glucocerebrosidase which are essential for Ceramide production. The other notable use for HMC is its ability to reduce capillary permeability for dark cicles around the eyes.
The benefits of HMC include: Anti-dark Circles, Antioxidant, Barrier Repair, and Anti-aging.
Properties of Hesperidin methylchalcone
| Melting point: | 120 °C (dec.)(lit.) |
| Boiling point: | 583.81°C (rough estimate) |
| alpha | -71 º (c=1 in ethanol) |
| Density | 1.3090 (rough estimate) |
| refractive index | 1.5940 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 6.71±0.40(Predicted) |
| color | Yellow |
| optical activity | [α]20/D 71°, c = 1 in ethanol |
| CAS DataBase Reference | 24292-52-2(CAS DataBase Reference) |
| EPA Substance Registry System | Hesperidin methylchalcone (24292-52-2) |
Safety information for Hesperidin methylchalcone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Hesperidin methylchalcone
| InChIKey | FDHNLHLOJLLXDH-JIYHLSBYSA-N |
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