Heptaethylene glycol

CAS NO.：5617-32-3
Empirical Formula: C14H30O8
Molecular Weight: 326.38
MDL number: MFCD00002876
EINECS: 227-040-3
SAFETY DATA SHEET (SDS)
Update Date: 2025-11-16 10:30:15

What is Heptaethylene glycol?

Description

Heptaethylene glycol contains repeating ethylene glycol subunits and two terminal hydroxyl groups. The hydroxyl groups can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of a compound in aqueous media. The water solubility properties of the PEG linker are enhanced with longer PEG chains.

The Uses of Heptaethylene glycol

Heptaethylene Glycol is used for the preparation of large ring crown ether compounds.

Definition

ChEBI: Heptaethylene glycol is a poly(ethylene glycol).

General Description

Heptaethylene glycol belongs to the class of organic compounds known as polyethylene glycols. These are oligomers or polymers of ethylene oxide, with the general formula (C2H4O)n (with n>=3). It is an extremely weak basic (essentially neutral) compound (based on its pKa). Heptaethylene glycol is a PEG-based PROTAC linker that can be used to synthesise PROTACs.

Properties of Heptaethylene glycol

Boiling point:	244 °C / 0.6mmHg
Density	1.13
refractive index	1.4653 (589.3 nm 20℃)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Ethyl Acetate (Sparingly)
pka	14.06±0.10(Predicted)
form	Oil
color	Colourless
InChI	InChI=1S/C14H30O8/c15-1-3-17-5-7-19-9-11-21-13-14-22-12-10-20-8-6-18-4-2-16/h15-16H,1-14H2
EPA Substance Registry System	Heptaethylene glycol (5617-32-3)

Safety information for Heptaethylene glycol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.