HEMICHOLINIUM-3
- CAS NO.：312-45-8
- Empirical Formula: C24H34N2O4.2Br
- Molecular Weight: 574.351
- MDL number: MFCD00011978
- EINECS: 206-227-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-05 08:30:42
What is HEMICHOLINIUM-3?
The Uses of HEMICHOLINIUM-3
Hemicholinium-3 has been used in the preparation of Krebs-HC-3 buffer to study its effects on choline uptake and choline acetyltransferase activity in differentiated human neuroblastoma (SK-N-SH) cells.
The Uses of HEMICHOLINIUM-3
Acetylcholine stores depletor
The Uses of HEMICHOLINIUM-3
Research tool as cholinergic probe, to deplete acetylcholine stores.
Biochem/physiol Actions
Hemicholinium-3 plays a role in blocking the neuronal choline uptake thereby inhibiting acetylcholine synthesis in the brain.
Properties of HEMICHOLINIUM-3
| Melting point: | 180°; mp 226- 228° (dec) |
| storage temp. | Store at -20°C |
| solubility | ethanol: 1.3 mg/mL |
| form | solid |
| color | white |
| Water Solubility | Water : 33.33 mg/mL (58.03 mM; Need ultrasonic) |
| Merck | 13,4660 |
| BRN | 5704458 |
| EPA Substance Registry System | Morpholinium, 2,2'-[1,1'-biphenyl]-4,4'-diylbis[2-hydroxy-4,4-dimethyl-, dibromide (312-45-8) |
Safety information for HEMICHOLINIUM-3
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for HEMICHOLINIUM-3
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