H3B-120

CAS NO.：2194903-42-7
Empirical Formula: C19H24N4O2S
Molecular Weight: 372.48
MDL number: MFCD32693918
Update Date: 2026-04-24 14:58:13

What is H3B-120?

Biological Activity

H3B-120 is a competitive and selective allosteric inhibitor of carbamoyl phosphate synthetase 1 (CPS1) with IC50 of 1.5 μM and Ki of 1.4 μM. H3B-120 exhibits antitumor activity.

in vitro

H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase).
It achieves inhibition by binding to an allosteric pocket situated between the integrating and ATP A domains.
Also H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays.
The half-life of H3B-120 is only 40 min.

Properties of H3B-120

Density	1.280±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 62.5 mg/mL (167.79 mM)
pka	8.28±0.70(Predicted)
form	Solid
color	Off-white to yellow

Safety information for H3B-120

Computed Descriptors for H3B-120

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