H-THR-PHE-LEU-LEU-ARG-NH2 TRIFLUOROACETATE SALT
Synonym(s):L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl- L-argininamide trifluoroacetate salt;Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt
- Empirical Formula: C33H54F3N9O8
- Molecular Weight: 761.83
- MDL number: MFCD05663482
- Update Date: 2025-08-21 11:10:20
What is H-THR-PHE-LEU-LEU-ARG-NH2 TRIFLUOROACETATE SALT?
The Uses of H-THR-PHE-LEU-LEU-ARG-NH2 TRIFLUOROACETATE SALT
TFLLR-NH2 trifluoroacetate salt has been used as a protease-activated receptor-1 (PAR-1) agonist to study its effects on hippocampal CA1 pyramidal neurons and Swell1 knock out mice (cKO).
Biochem/physiol Actions
TFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.
Properties of H-THR-PHE-LEU-LEU-ARG-NH2 TRIFLUOROACETATE SALT
| storage temp. | -20°C |
| form | lyophilized powder |
| color | white to tan |
Safety information for H-THR-PHE-LEU-LEU-ARG-NH2 TRIFLUOROACETATE SALT
Computed Descriptors for H-THR-PHE-LEU-LEU-ARG-NH2 TRIFLUOROACETATE SALT
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