H-GLY-PRO-ARG-PRO-NH2
Synonym(s):Glycine-Proline-Arginine-Proline amide;Glycyl-L-prolyl-L-arginyl-L-prolinamide;GPRP amide
- CAS NO.：126047-75-4
- Empirical Formula: C18H32N8O4
- Molecular Weight: 424.5
- MDL number: MFCD00237962
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:19:52
What is H-GLY-PRO-ARG-PRO-NH2?
The Uses of H-GLY-PRO-ARG-PRO-NH2
Gly-Pro-Arg-Pro amide has been used-
- as a constituent of buffer during fluid-phase and bound thrombin inhibition assays, to determine the activity of thrombin
- for blocking fibrin polymerization and preventing fibrin clot formation in presence of α-thrombin, in blood obtained from mice
- during preparation of human soluble fibrin, to block the polymerization of soluble fibrin
General Description
Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the a chain of fibrin protein.
Biochem/physiol Actions
Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid).
Properties of H-GLY-PRO-ARG-PRO-NH2
| storage temp. | -20°C |
Safety information for H-GLY-PRO-ARG-PRO-NH2
Computed Descriptors for H-GLY-PRO-ARG-PRO-NH2
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