H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH

CAS NO.：143413-47-2
Empirical Formula: C54H110N36O10
Molecular Weight: 1423.69
MDL number: MFCD08458590
SAFETY DATA SHEET (SDS)
Update Date: 2025-08-21 22:16:43

What is H-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-ARG-OH?

What are the applications of Application

(Arg)9 is a cell-penetrating peptide made up of 9 arginine residues

Biological Activity

(Arg)9 (Nona-L-arginine; Peptide R9) is a cell-permeable polypeptide with IC50 value of 0.78 μM for neuroprotection in a glutamate model experimental model.

in vitro

Poly-arginine (eg (Arg)9) and arginine-rich peptides (eg TAT, penetratin), which belong to a class of peptides with cell-penetrating properties are neuroprotective. It provides significant neuroprotection in a dose–response manner following glutamic acid exposure (IC ₅₀ =0.78 μM). Following kainic acid exposure, (Arg)9 is neuroprotective, but less effective than in the glutamic acid model (IC ₅₀ =0.81 μM). (Arg)9 also shows neuroprotection following in vitro ischemia (IC ₅₀ =6 μM).

in vivo

(Arg)9) (D-isoform) is neuroprotective in rat stroke models. (Arg)9) is highly neuroprotective, with efficacy increasing with increasing arginine content, has the capacity to reduce glutamic acid-induced neuronal calcium influx and requires heparan sulfate preotoglycan-mediated endocytosis to induce a neuroprotective effect. (Arg)9) (D-isoform) administered intravenously at a dose of 1000 nmol/kg 30 min after reduces permanent middle cerebral artery occlusion (MCAO) infarct volume .