Gymnoascolide A

CAS NO.：865092-05-3
Empirical Formula: C17H14O2
Molecular Weight: 250.29
MDL number:
Update Date: 2025-04-17 18:22:24

What is Gymnoascolide A?

Biological Activity

Gymnoascolide A is a fungal metabolite originally isolated from G. reessii that has fungicidal and vasodilatory activities.1,2 It is active against the phytopathogenic fungus S. nodorum (MIC = 13 μg/ml) but not C. albicans, B. subtilis, or the ruminant pathogenic nematode H. contortus in an agar diffusion assay.1,2 Gymnoascolide A (1 μM) inhibits calcium-induced contractions in isolated rat aortic rings.2

References

1.Clark, B., Capon, R.J., Lacey, E., et al.Gymnoascolides A-C: Aromatic butenolides from an Australian isolate of the soil Ascomycete Gymnoascus reessiiJ. Nat. Prod.68(8)1226-1230(2005) 2.Hosoe, T., Iizuka, T., Komai, S., et al.4-Benzyl-3-phenyl-5H-furan-2-one, a vasodilator isolated from Malbranchea filamentosa IFM 41300Phytochem.66(23)2776-2779(2005)

Properties of Gymnoascolide A

Boiling point:	466.7±44.0 °C(Predicted)
Density	1.203±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
form	A solid

Safety information for Gymnoascolide A

Computed Descriptors for Gymnoascolide A

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