Gyki 52466 hydrochloride
Synonym(s):1-(4-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
- CAS NO.：102771-26-6
- Empirical Formula: C17H16ClN3O2
- Molecular Weight: 329.78
- MDL number: MFCD00885518
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:56:34
What is Gyki 52466 hydrochloride?
The Uses of Gyki 52466 hydrochloride
4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)benzenamine is a non-competitive AMPA receptor antagonist and was found to have therapeutic potential for cocaine addiction treatment.
What are the applications of Application
GYKI 52466 hydrochloride is a selective non-competitive allosteric AMPA receptor antagonist
Definition
ChEBI: GYKI 52466 is a benzodiazepine.
Biological Activity
Selective non-competitive AMPA receptor antagonist (IC 50 values are 10-20, ~ 450 and >> 50 μ M for AMPA- , kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. Has anti-proliferative effects in transformed cells. Also available as part of the AMPA Receptor Tocriset™ . Also available as part of the Kainate Receptor Tocriset™ .
Storage
room temperature (desiccate)
Properties of Gyki 52466 hydrochloride
| Boiling point: | 472.8±45.0 °C(Predicted) |
| Density | 1.39 |
| storage temp. | Desiccate at RT |
| solubility | DMSO: 0.39 mg/mL |
| form | solid |
| pka | 8.14±0.20(Predicted) |
| color | yellow |
Safety information for Gyki 52466 hydrochloride
Computed Descriptors for Gyki 52466 hydrochloride
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