GYKI 47261 DIHYDROCHLORIDE

CAS NO.：220445-20-5
Empirical Formula: C18H15ClN4
Molecular Weight: 322.79
MDL number: MFCD11519959
SAFETY DATA SHEET (SDS)
Update Date: 2025-04-17 18:22:24

What is GYKI 47261 DIHYDROCHLORIDE?

The Uses of GYKI 47261 DIHYDROCHLORIDE

GYKI 47261 dihydrochloride is a non-competitive AMPA antagonist receptor.

Biological Activity

Non-competitive AMPA receptor antagonist (IC 50 = 2.5 μ M). Displays broad spectrum anticonvulsive activity and neuroprotective effects in vivo .

References

[1]. abrahám g, sólyom s, csuzdi e, et al. new non competitive ampa antagonists. bioorg med chem, 2000, 8(8): 2127-2143.
[2]. tamási v, hazai e, porsmyr-palmertz m, et al. gyki-47261, a new ampa [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a cyp2e1 inducer. drug metab dispos, 2003, 31(11): 1310-1314.
[3]. bibbiani f, oh jd, kielaite a, et al. combined blockade of ampa and nmda glutamate receptors reduces levodopa-induced motor complications in animal models of pd. exp neurol, 2005, 196(2): 422-429.

Properties of GYKI 47261 DIHYDROCHLORIDE

storage temp.	Store at +4°C
solubility	<35.92mg/ml in DMSO
form	solid
color	Yellow

Safety information for GYKI 47261 DIHYDROCHLORIDE

Computed Descriptors for GYKI 47261 DIHYDROCHLORIDE

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