Guvacoline Hydrobromide
- CAS NO.：17210-51-4
- Empirical Formula: C7H12BrNO2
- Molecular Weight: 222.07968
- MDL number: MFCD02683335
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-04 15:05:55
What is Guvacoline Hydrobromide?
Chemical properties
Crystalline Solid
The Uses of Guvacoline Hydrobromide
A muscarinic receptor used as nootropic agent.
What are the applications of Application
Guvacoline, Hydrobromide is helpful tool used to identify muscarinic receptors
Biological Activity
guvacoline is a kind of natural alkaloid which is found in areca nuts that is related to the nootropic, arecoline. guvacoline can function as a full agonist of atrial and ileal muscarinic receptors.in vitro: in human buccal epithelial cells, guvacoline could significantly decrease the colony-formation efficiency in a dose dependent manner, with the ic50 value of 2.1 mm. besides, guvacoline could also dose-dependently reduce the amount of total free low-molecular-weight thiols (0.88 mm guvacoline caused 25% decrease) and increase the number of single strand breaks [1].
References
[1] k. sundqvist, y. liu, j. nair, et al. cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. cancer research 49(19), 5294-5298 (1989).
Properties of Guvacoline Hydrobromide
| Melting point: | 144°C |
| storage temp. | -20°C Freezer |
| solubility | ≤1mg/ml in DMSO;1mg/ml in dimethyl formamide |
| form | crystalline solid |
Safety information for Guvacoline Hydrobromide
Computed Descriptors for Guvacoline Hydrobromide
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