GSK864

Synonym(s):(S)-1-(4-Fluorobenzyl)-N3-(4-methoxy-3,5-dimethylphenyl)-7-methyl-5-(1H-pyrrole-2-carbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3,7-dicarboxamide

CAS NO.：1816331-66-4
Empirical Formula: C30H31FN6O4
Molecular Weight: 558.6
MDL number: MFCD30478507
Update Date: 2026-04-24 14:59:00

What is GSK864?

Biochem/physiol Actions

GSK864 is a cell penetrant, potent and selective allosteric inhibitor of isocitrate dehydrogenase 1 (IDH1) that potently inhibits intracellular 2-hydroxyglutarate (2-HG) production in HT-1080 cells. It appears that GSK864 binds to an allosteric binding site and locks WT and mutant IDH1s in a catalytically inactive conformation. GSK864 is a highly bioavailable analog of GSK321. For full characterization details, please visit the GSK864 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc

Properties of GSK864

Boiling point:	782.9±60.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF:20.0(Max Conc. mg/mL);35.8(Max Conc. mM) DMSO:60.0(Max Conc. mg/mL);107.41(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);35.8(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.9(Max Conc. mM)
pka	11.73±0.70(Predicted)
form	powder
color	white to beige
optical activity	[α]/D -66 to -76°, c = 0.5 in methanol