GSK840

CAS NO.：2361146-30-5
Empirical Formula: C21H23N3O3
Molecular Weight: 365.43
Update Date: 2025-04-18 09:53:10

What is GSK840?

Biological Activity

GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, binds with high affinity to the RIP3 kinase domain with an IC50 of 0.9 nM, and inhibits kinase activity with an IC50 of 0.3 nM.

in vitro

GSK840 (GSK'840) (0.01-3 μM; 24 hours) blocks TNF-induced necroptosis in a concentration-dependent manner.
GSK840 binds the kinase domain and inhibits kinase activity with high specificity, targeting a broader range of pro-necrotic stimuli than can be achieved with RIP1 kinase inhibitors.

Cell Viability Assay

Cell Line:	Human HT-29 cells (TNF 10 ng/ml + zVAD-fmk 20 μM + SMAC007 100 nM)
Concentration:	0.01-3 μM
Incubation Time:	24 hours
Result:	Blocked TNF-induced necroptosis in a concentration-dependent manner.

Properties of GSK840

Density	1.18±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	110 mg/mL in DMSO
form	Solid
pka	14.16±0.46(Predicted)
color	Light yellow to yellow

Safety information for GSK840

Computed Descriptors for GSK840

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