GSK255B)
- CAS NO.:1366233-41-1
- Empirical Formula: C18H19ClFN3O3S
- Molecular Weight: 411.88
- MDL number: MFCD34469310
- Update Date: 2025-04-18 09:51:54
What is GSK255B)?
Description
GSK 2332255B is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 3 nM/21 nM, respectively. It dispalys >100-fold selectivity over other calcium-permeable channels. It has 100-fold greater potency for TRPC3 compared with Pyr3. GSK 2332255B (dose-dependent) blocks cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes.
Properties of GSK255B)
| Boiling point: | 542.7±60.0 °C(Predicted) |
| Density | 1.417±0.06 g/cm3(Predicted) |
| pka | 0.46±0.10(Predicted) |
Safety information for GSK255B)
Computed Descriptors for GSK255B)
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