GSK2194069

Synonym(s):(S)-4-(4-(Benzofuran-5-yl)phenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one

CAS NO.：1332331-08-4
Empirical Formula: C25H24N4O3
Molecular Weight: 428.48
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-27 17:00:41

What is GSK2194069?

The Uses of GSK2194069

GSK 2194069 is a potent human fatty acid synthase (hFASN) inhibitor.

Biochem/physiol Actions

GSK2194069 is a fatty acid synthase (FAS) inhibitor. GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.7 ± 4.1 nM for the overall hFAS reaction. FAS is upregulated in some cancers, including prostate cancer. GSK2194069 was found to inhibit tumour growth in prostate cancer C42b cell xenografts generated in Nod-SCID-gamma mice. Cellular FAS inhibition reduced cell growth were also demonstrated in non-small-cell lung (A549) cancer cell lines with an average EC50 of 15 ± 0.5 nM.

Storage

Store at +4°C

Properties of GSK2194069

Density	1.44±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF:30.0(Max Conc. mg/mL);70.01(Max Conc. mM) DMSO:54.28(Max Conc. mg/mL);126.68(Max Conc. mM) Ethanol:4.91(Max Conc. mg/mL);11.46(Max Conc. mM)
form	powder
pka	6.15±0.20(Predicted)
color	white to light brown

Safety information for GSK2194069

Computed Descriptors for GSK2194069

New Products

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