GSK2194069

Synonym(s):(S)-4-(4-(Benzofuran-5-yl)phenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1H-1,2,4-triazol-5(4H)-one

CAS NO.：1332331-08-4
Empirical Formula: C25H24N4O3
Molecular Weight: 428.48
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-20 17:00:22

What is GSK2194069?

The Uses of GSK2194069

GSK 2194069 is a potent human fatty acid synthase (hFASN) inhibitor.

Biochem/physiol Actions

GSK2194069 is a fatty acid synthase (FAS) inhibitor. GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.7 ± 4.1 nM for the overall hFAS reaction. FAS is upregulated in some cancers, including prostate cancer. GSK2194069 was found to inhibit tumour growth in prostate cancer C42b cell xenografts generated in Nod-SCID-gamma mice. Cellular FAS inhibition reduced cell growth were also demonstrated in non-small-cell lung (A549) cancer cell lines with an average EC50 of 15 ± 0.5 nM.

Storage

Store at +4°C

Properties of GSK2194069

Density	1.44±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF:30.0(Max Conc. mg/mL);70.01(Max Conc. mM) DMSO:54.28(Max Conc. mg/mL);126.68(Max Conc. mM) Ethanol:4.91(Max Conc. mg/mL);11.46(Max Conc. mM)
form	powder
pka	6.15±0.20(Predicted)
color	white to light brown

Safety information for GSK2194069

Computed Descriptors for GSK2194069

New Products

2-(2-Ethoxyphenoxy)ethyl bromide 1,3-Dibromo-2,2-dimethoxypropane 8-Bromo-7-(2-butynyl)-3-methyl xanthine 5-Chlorothiophene-2-carboxylic acid 8-Bromo-3-methyl xanthine Maleic hydrazide o-Anisaldehyde 4-Bromobenzaldehyde 3-Fluorobenzaldehyde 2-Chlorobenzaldehyde 3-Amino-3-(3-fluorophenyl)propanoic acid 1-Propyl-4-piperidone 2,3-Dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-1H-inden-1-one hydrochloride 3-(4-Bromo-3-methyl-2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)piperidine-2,6-dione 2-Fluoro-6-iodobenzoic acid 3-Pyridineacrylic acid 1-Boc-4-cyanopiperidine ethyl 2-oxo-2,3,9,10-tetrahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate Vardenafil Bis-sulphonamide(Dimer) Nitroso Irbesartan N-Nitroso Nortriptyline Sulfonic acid Impurity 2-(p-Tolyl)acetaldehyde 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one