GSK-1605786
- CAS NO.：698394-73-9
- Empirical Formula: C22H21ClN2O4S
- Molecular Weight: 444.93
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-10-29 15:43:00
What is GSK-1605786?
Description
Vercirnon is an orally bioavailable antagonist of chemokine receptor 9 (CCR9) with an IC50 value of 5.4 nM for inhibition of CCL25-induced calcium mobilization in Molt-4 cells. It is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s = >10 μM for all). It also inhibits CCL25-induced Molt-4 chemotaxis in 0.1% BSA/HBSS and in 100% human AB serum (IC50s = 3.5 and 33.4 nM, respectively), as well as chemotaxis of human T cells stimulated by retinoic acid (RA) and mouse and rat thymocytes. Vercirnon binds allosterically to the intracellular side of CCR9 and prevents G protein coupling.
Properties of GSK-1605786
| Boiling point: | 672.3±65.0 °C(Predicted) |
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 25 mg/ml |
| form | A crystalline solid |
| pka | 7.07±0.10(Predicted) |
| color | White to off-white |
Safety information for GSK-1605786
Computed Descriptors for GSK-1605786
New Products
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