GSA 10

CAS NO.：300833-95-8
Empirical Formula: C26H30N2O5
Molecular Weight: 450.53
MDL number: MFCD01128015
SAFETY DATA SHEET (SDS)
Update Date: 2026-08-05 19:35:02

What is GSA 10?

Description

Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC₅₀ = 1.2 μM). Most notably, GSA 10 does not recognize the classic cyclopamine binding site as do other SMO agonists and as such has been used to characterize a novel SMO active site.

The Uses of GSA 10

GSA 10 is a novel small-molecule positive modulator of smoothened. GSA 10 may have therapeutic interests in regenerative medicine.

What are the applications of Application

GSA 10 is a smoothened (Smo) receptor agonist

Properties of GSA 10

Boiling point:	620.2±55.0 °C(Predicted)
Density	1.240±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble to 5 mM in DMSO with gentle warming
form	Powder
pka	4.50±1.00(Predicted)
color	White to light yellow

Safety information for GSA 10

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for GSA 10

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