Growth hormone releasing peptide

Description

Growth hormone-releasing peptides (GHRPs) are synthetic, non-endogenous peptides that potently stimulate somatotrope secretion in both animal and human subjects. Structurally, they lack homology with Growth Hormone-Releasing Hormone (GHRH). GHRPs exert their action by binding to specific receptors located at the pituitary and/or hypothalamic levels in both animals and humans.

The Uses of Growth hormone releasing peptide

Growth hormone releasing peptide-6 can promote the secretion of growth hormone, regulate food intake, increase weight, and promote animal growth.

The Uses of Growth hormone releasing peptide

L-Histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide is a growth hormone releasing peptide.

Benefits

Administration of Growth Hormone-Releasing Peptide (GHRP) initiates a selective signal to the brain, stimulating the hypothalamus and anterior pituitary to release growth hormone (GH). The released GH preferentially targets muscle tissue to support development, without promoting bone or cartilage growth. Injection of the peptide enhances cellular synthesis, increases insulin secretion from pancreatic tissue, and elevates ghrelin levels in the stomach, which facilitates GH release and appetite regulation. Collectively, these functions contribute to fat loss, optimized nutrient partitioning, and the accrual of lean muscle mass.

Mechanism of action

It is generally accepted that Growth Hormone-Releasing Peptides (GHRPs) stimulate Growth Hormone (GH) release by acting at the pituitary level through a receptor distinct from that of the endogenous Growth Hormone-Releasing Hormone (GHRH). Furthermore, specific binding sites for these peptides have been identified in the hypothalamus. Systemic GHRP administration has been shown to increase the expression of the immediate early gene c-fos within a subpopulation of hypothalamic neurons.

Side Effects

Carpal tunnel syndrome.Increased insulin resistance.
Type 2 diabetes.
Swelling in the arms and legs (edema)
Joint and muscle pain.
For men, enlargement of breast tissue (gynecomastia).
Increased risk of certain cancers.

Physiological effects

Growth hormone releasing peptide (GHRP) is a cyclase inhibitor that blocks the release of endogenous growth hormone.The peptide acts on both igf-i and somatotrophs, with receptor activity in the hypothalamus.GHRP can be used to increase body weight and control obesity.It has been shown to stimulate cell division and inhibit apoptosis in vitro.

Solubility in water

It is recommended to reconstitute the lyophilized growth hormone releasing peptide in sterile 18MΩ-cm H₂O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.

Storage

Lyophilized Growth hormone releasing peptide although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Growth hormone releasing peptide should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.