GR 113808
Synonym(s):1-[2-[(Methylsulfonyl)-amino]ethyl]-4-piperidinyl]methyl 1-methyl-1H-indole-3-carboxylate;5-HT₄ Serotonin Receptor Antagonist, GR113808, GR 113808, GR-113808;GR113808 - CAS 144625-51-4 - Calbiochem
- CAS NO.：144625-51-4
- Empirical Formula: C19H27N3O4S
- Molecular Weight: 393.5
- MDL number: MFCD00912901
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:26:23
What is GR 113808?
The Uses of GR 113808
GR 113808 has been used as a serotonin receptor 4 (5-HT4R) blocker to study its effects on the calcium (Ca2+) transients in rat ventricular cardiomyocytes. It has also been used as a 5-HT4R antagonist to study its effects on de novo enteric neurogenesis in post-embryonic zebrafish.
What are the applications of Application
GR 113808 is a robust and selective receptor antagonist of SR-4
Definition
ChEBI: An indolyl carboxylate ester obtained by formal condensation between the carboxy group of 1-methylindole-3-carboxylic acid with the hydroxy group of N-{2-[4-(hydroxymethyl)piperidin-1-yl]ethyl}methanesulfonamide.
Biological Activity
Potent, selective 5-HT 4 receptor antagonist (pK B = 9.43 in human colonic muscle, and K d = 0.15 nM for binding to cloned human 5-HT 4 receptors). Displays > 300-fold selectivity over 5-HT 1A , 5-HT 1B , 5-HT 2A , 5-HT 2C and 5-HT 3 receptors.
Biochem/physiol Actions
GR 113808 is a 5-HT4 serotonin receptor antagonist.
Storage
Store at RT
Properties of GR 113808
| Boiling point: | 572.3±53.0 °C(Predicted) |
| Density | 1.30±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 44 mg/mL, soluble |
| form | solid |
| pka | 11.22±0.40(Predicted) |
| color | white |
Safety information for GR 113808
Computed Descriptors for GR 113808
New Products
Dexamethasone Sodium Phosphate p-Anisaldehyde m-Tolualdehyde 2-Bromobenzaldehyde 4-Fluorobenzaldehyde 1-Propyl-4-piperidone 3-Amino-3-(3-fluorophenyl)propanoic acid Raloxifene EP Impurity D N-Nitroso Nortriptyline Nitroso Irbesartan 2-(p-Tolyl)acetaldehyde Sulfonic acid Impurity 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one 5-Chloro-2-Methoxy-4-Picoline 2-Amino-6-nitrobenzoic Acid (6-Nitroanthranilic acid) Cis-3,5 Diacetoxy-1-cyclopentene 3-Bromo-2-Methoxy-4-Methylpyridine 2-Amino-5-Chloro-3-Nitro-6-picoline 3-Methoxy-5-methylpyrazin-2-amine Pentachlorobenzonitrile Budesonide Nicotinic acid RAPAMYCIN Alpha CyclodextrinRelated products of tetrahydrofuran
![[3H]GR-113808](https://img.chemicalbook.in/StructureFile/ChemBookStructure4/GIF/CB2348519.gif)
![[1-(2-aminoethyl)-4-piperidinyl]methanol](https://img.chemicalbook.in/CAS/GIF/129999-62-8.gif)
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