GNF-6231

CAS NO.：1243244-74-7
Empirical Formula: C25H28N6O2
Molecular Weight: 444.53
Update Date: 2023-03-31 09:12:58

What is GNF-6231?

Description

GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50=0.8 nM (Wnt3a Co-culture RGA). GNF-6231 demonstrated excellent pathway inhibition and induced robust antitumor efficacy in a mouse MMTV-WNT1 xenograft tumor model. Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. Wnt signaling is tightly controlled during cellular proliferation, differentiation, and embryonic morphogenesis. Aberrant activation of this pathway plays a critical role in a variety of cancers, such as cutaneous squamous cell carcinoma (SCC), breast cancer, and colorectal cancer.

Properties of GNF-6231

Boiling point:	728.7±60.0 °C(Predicted)
Density	1.251±0.06 g/cm3(Predicted)
pka	12?+-.0.70(Predicted)

Safety information for GNF-6231

Computed Descriptors for GNF-6231

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