GNE-6640

CAS NO.：2009273-60-1
Empirical Formula: C21H21N3O2
Molecular Weight: 347.41
MDL number: MFCD34167533
Update Date: 2026-04-21 10:31:43

What is GNE-6640?

Biological Activity

USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects[1]. USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4[1].

References

[1]. Robert Blake, et al. Usp7 inhibitor compounds and methods of use. US20160272588A1.

Properties of GNE-6640

Boiling point:	590.1±50.0 °C(Predicted)
Density	1.210±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 83.33 mg/mL (239.86 mM; Need ultrasonic)
form	Solid
pka	8.20±0.15(Predicted)
color	Off-white to brown

Safety information for GNE-6640

Computed Descriptors for GNE-6640

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