USP7-IN-8
- CAS NO.：2009273-60-1
- Empirical Formula: C21H21N3O2
- Molecular Weight: 347.41
- MDL number: MFCD34167533
- Update Date: 2026-07-27 17:00:41
What is USP7-IN-8?
Biological Activity
USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects[1]. USP7 or HAUSP (herpesvirus-associated USP) is a ubiquitin specific protease or a deubiquitylating enzyme that cleaves ubiquitin from its substrates. USP7 is a eubiquitinase (DUB) that controls cell proliferation by altering the stability of Mdm2, p53, PTEN and FOXO4[1].
References
[1]. Robert Blake, et al. Usp7 inhibitor compounds and methods of use. US20160272588A1.
Properties of USP7-IN-8
| Boiling point: | 590.1±50.0 °C(Predicted) |
| Density | 1.210±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 83.33 mg/mL (239.86 mM; Need ultrasonic) |
| form | Solid |
| pka | 8.20±0.15(Predicted) |
| color | Off-white to brown |
Safety information for USP7-IN-8
Computed Descriptors for USP7-IN-8
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