Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

CAS NO.：325970-71-6
Empirical Formula: C16H14Br2N4O4
Molecular Weight: 486.11
MDL number: MFCD00363966
Update Date: 2026-01-27 08:46:37

What is Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide?

Description

L67 is a competitive inhibitor of DNA ligases I and III (IC₅₀s = 10 and 10 μM for human DNA ligase I and human ligase IIIβ). It blocks DNA binding (K_i = 10 μM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells. It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 μM.

The Uses of Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

L 67 is used in the identification and validation of human DNA ligase inhibitors using computer-aided grug design.

Properties of Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

storage temp.	Store at -20°C
solubility	DMSO:21.5(Max Conc. mg/mL);44.23(Max Conc. mM) DMF:10.0(Max Conc. mg/mL);20.57(Max Conc. mM) Water:1.0(Max Conc. mg/mL);2.06(Max Conc. mM)
form	A crystalline solid
color	Light yellow to yellow

Safety information for Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

Signal word	Danger
Pictogram(s)	Exclamation Mark Irritant GHS07 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H361:Reproductive toxicity H372:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

Computed Descriptors for Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

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