GLY-ARG-GLY-ASP-SER-PRO-LYS

Synonym(s):GRGDSPK

CAS NO.：111119-28-9
Empirical Formula: C28H49N11O11
Molecular Weight: 715.76
MDL number: MFCD00076462
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:13

What is GLY-ARG-GLY-ASP-SER-PRO-LYS?

The Uses of GLY-ARG-GLY-ASP-SER-PRO-LYS

Gly-Arg-Gly-Asp-Ser-Pro-Lys (RGD peptide) has been used-

as a blocking peptide to inhibit integrin-fibronectin binding
in adhesion assay performed on porcine trophectoderm to study the influence of TGFβ (transforming growth factor) on cell adhesion
for incubation of MC3T3-E1 osteoblast cells to determine its effect on cell adhesion measured by AFM (atomic force microscopy)
for the preparation of RGD.Flt23k.NR nanoparticles
to determine the involvement of RGD-integrin bonding in cell adhesion process

General Description

Gly-Arg-Gly-Asp-Ser-Pro-Lys is a RGD peptide. Naturally occurring RGD peptides, present in the ECM (extracellalar matrix) proteins, are involved in facilitating integrin-mediated cell adhesion to matrix proteins. RGD peptide is present as repeats in cell-adhesion protein, such as fibronectin and vitronectin. This tripeptide is recognized by cells by specific integrins (e.g. β1 , β3 , and β5 subunits), present on the cell surface and associated with the actin filament via the FA (focal adhesion)-complex.