GLY-ARG-GLY-ASP-SER

Synonym(s):GRGDS;H-Gly-Arg-Gly-Asp-Ser-OH - CAS 96426-21-0 - Calbiochem

CAS NO.：96426-21-0
Empirical Formula: C17H30N8O9
Molecular Weight: 490.47
MDL number: MFCD00076459
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is GLY-ARG-GLY-ASP-SER?

The Uses of GLY-ARG-GLY-ASP-SER

Gly-Arg-Gly-Asp-Ser has been used-

as an antigen to determine whether integrin α4 or α5 hinders the adhesion of day 3 postirradiation thymocytes to thymic epithelial cells, in mice
for the treatment of collagen IV-coated dishes to study the role of integrins α1, αv, β1, and β3 in Sca-1⁺ progenitor cell differentiation into SMCs (smooth muscle cells)
as a blocking peptide for the pre-incubation of Nisseria meningitides strains, to perform blocking experiments to study the interactions between these bacterial strains and fibronectin
for the pre-treatment of EL-4 cells infected by AdCMV-GFP (cytomegalovirus-green fluorescent protein), to study whether interaction with cellular integrins is essential for the transduction of adenovirus

General Description

Gly-Arg-Gly-Asp-Ser peptide sequence is identical to the cell-binding region of fibronectin protein. Arg-Gly-Asp (RGD) region is found in various proteins, and is crucial for facilitating cell-adhesive activity.

Biochem/physiol Actions

Antagonist of integrin function

Properties of GLY-ARG-GLY-ASP-SER

Density	1.66±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO : 100 mg/mL (203.89 mM);Water : 33.33 mg/mL (67.96 mM)
form	White to off-white lyophilized solid
pka	2.85±0.10(Predicted)
color	White to off-white