GLX351322

CAS NO.：835598-94-2
Empirical Formula: C21H25N3O5S
Molecular Weight: 431.51
MDL number: MFCD05123600
Update Date: 2026-07-27 17:00:41

What is GLX351322?

Biological Activity

GLX351322 is an inhibitor of NADPH oxidase 4 (NOX4). It can inhibits tetracycline-induced hydrogen peroxide production in NOX4-overexpressing cells with IC50 of 5 μM.

in vitro

GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC ₅₀ of 5 μM. GLX351322 shows weak activity against NOX2 in hPBMC cells ( IC ₅₀ , 40 μM).

in vivo

GLX351322 (3.8 mg/kg/day, po) ameliorates HFD-induced hyperglycemia in mice.

Properties of GLX351322

solubility	DMSO:20.0(Max Conc. mg/mL);46.35(Max Conc. mM) DMF:1.0(Max Conc. mg/mL);2.32(Max Conc. mM) DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.76(Max Conc. mM) Ethanol:4.0(Max Conc. mg/mL);9.27(Max Conc. mM)
form	A crystalline solid
color	White to off-white

Safety information for GLX351322

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for GLX351322

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