glucagon receptor antagonists-4
- CAS NO.：1393124-08-7
- Empirical Formula: C26H28F3N3O4
- Molecular Weight: 503.51
- MDL number: MFCD30343861
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-08-02 18:55:13
What is glucagon receptor antagonists-4?
The Uses of glucagon receptor antagonists-4
PF-06291874 is a novel and potent glucagon receptor antagonist for the potential treatment of diabetes mellitus. PF-06291874, has a lower molcular weight and lipophilicity than historical glucagon receptor antagonists, resulting in excellent selectivity in broad-panel screening, lower cytotoxicity, and excellent overall in vivo safety in early pre-clinical testing.
Properties of glucagon receptor antagonists-4
| Boiling point: | 675.0±55.0 °C(Predicted) |
| Density | 1.27±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 50mg/mL; DMSO: 50mg/mL; DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL; Ethanol: 0.5mg/mL |
| form | A crystalline solid |
| pka | 4.28±0.10(Predicted) |
| color | White to off-white |
Safety information for glucagon receptor antagonists-4
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for glucagon receptor antagonists-4
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