GLP-26

CAS NO.：2133017-36-2
Empirical Formula: C19H17F2N3O3
Molecular Weight: 373.36
MDL number: MFCD32201067
Update Date: 2026-07-14 16:49:18

What is GLP-26?

Description

GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM), and reduces cccDNA by >90% at 1 μM.GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools[1].

GLP-26 (0.7-1.7 μM; 3 days) reduces secreted HBeAg in HepNTCP-DL cells transfected with HBVwild type, with EC50 values of 0.7 μM[2]. Cell Viability Assay[2] Cell Line: HepNTCP-DL cells

References

[1]. Nijampatnam B, et al. Recent advances in the development of HBV capsid assembly modulators. Curr Opin Chem Biol. 2019 Jun;50:73-79.

Properties of GLP-26

Density	1.26±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 125 mg/mL (334.81 mM)
form	Solid
pka	10.99±0.46(Predicted)
color	Light yellow to brown

Safety information for GLP-26

Computed Descriptors for GLP-26

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