GGTI-286

CAS NO.：171744-11-9
Empirical Formula: C23H31N3O3S
Molecular Weight: 429.58
MDL number: MFCD09037530
Update Date: 2026-04-21 10:31:43

What is GGTI-286?

What are the applications of Application

GGTI-286 is a potent, selective, cell-permeable inhibitor of GGTase I

Biological Activity

GGTI-286, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276 . GGTI-286 selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s =2 and >30 μM, respectively). GGTI-286 also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM[1].

References

[1]. E C Lerner, et al. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J Biol Chem. 1995 Nov 10;270(45):26770-3. [2]. Naoyuki Nishiya, et al. A zebrafish chemical suppressor screening identifies small molecule inhibitors of the Wnt/β-catenin pathway. Chem Biol. 2014 Apr 24;21(4):530-540.

Properties of GGTI-286

Boiling point:	626.9±55.0 °C(Predicted)
Density	1.164±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	9.81±0.10(Predicted)

Safety information for GGTI-286

Computed Descriptors for GGTI-286

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