Gefitinib-based PROTAC 3
- CAS NO.：2230821-27-7
- Empirical Formula: C47H57ClFN7O8S
- Molecular Weight: 934.52
- Update Date: 2026-08-20 20:20:01
What is Gefitinib-based PROTAC 3?
Description
Gefitinib-based PROTAC 3 contains an EGFR binding element and a von Hippel-Lindau ligand joined by a linker which induces EGFR degradation.
The Uses of Gefitinib-based PROTAC 3
Gefitinib-based PROTAC 3 is useful for EGFR proteolysis targeting.
Storage
Store at -20°C
Properties of Gefitinib-based PROTAC 3
| Boiling point: | 1065.6±65.0 °C(Predicted) |
| Density | 1.300±0.06 g/cm3(Predicted) |
| storage temp. | 4°C, away from moisture and light |
| solubility | DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml; DMSO: 16 mg/ml; Ethanol: 10 mg/ml |
| form | A crystalline solid |
| pka | 14.07±0.40(Predicted) |
| color | Off-white to light yellow |
Safety information for Gefitinib-based PROTAC 3
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Gefitinib-based PROTAC 3
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