GDC-0853

CAS NO.：1434048-34-6
Empirical Formula: C37H44N8O4
Molecular Weight: 664.8
MDL number: MFCD30489729
Update Date: 2026-07-27 17:00:41

What is GDC-0853?

Description

GDC-0853 is an orally bioavailable, selective, and reversible Bruton’s tyrosine kinase (BTK) inhibitor with IC₅₀s ranging from 2-9 nM for basophil activation, B cell receptor activation, and constitutive p-BTK activity in whole blood lysates. In rats, treatment for longer than 7 days leads to pancreatic toxicity but it does not occur in mice or dogs, even at higher doses. Formulations containing GDC-0853 were well-tolerated in Phase I clinical trials and are in additional clinical trials for rheumatoid arthritis, lupus erythematosus, lymphoma, and leukemia.

The Uses of GDC-0853

Fenebrutinib is a selective and reversible oral small-molecular BTK inhibitor for the treatment of rheumatoid arthritis and systemic lupus erythematosus.

Properties of GDC-0853

Boiling point:	936.3±65.0 °C(Predicted)
Density	1.42±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF:20.0(Max Conc. mg/mL);30.08(Max Conc. mM) DMSO:17.0(Max Conc. mg/mL);25.57(Max Conc. mM) DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.5(Max Conc. mM) Ethanol:5.0(Max Conc. mg/mL);7.52(Max Conc. mM)
form	A crystalline solid
pka	13.15±0.10(Predicted)
color	White to off-white

Safety information for GDC-0853

Computed Descriptors for GDC-0853

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