GALLIUM NITRATE

The Uses of GALLIUM NITRATE

Regulator (calcium).

brand name

Ganite (Genta).

Clinical Use

Gallium nitrate (Ganite) has been approved for the treatment of hypercalcemia of malignancy in patients that do not respond to hydration. Its effectiveness stems from its ability to inhibit bone resorption despite the presence of tumor-derived factors that promote calcium loss from the bone. Administered by infusion over 24 hours, the typical dose is 200 mg/m2 /day for five consecutive days. A lower dose is recommended if the symptoms of hypercalcemia are mild (100 mg/m2 /day for 5 days). Steady state is achieved in 24 to 48 hours. Maintenance of patient hydration is essential during treatment.

Metabolism

Gallium nitrate is not significantly metabolized and is largely excreted through the kidneys. It is contraindicated in patients with severe renal impairment. Renal function should be closely monitored in all patients receiving this agent.