GALAXOLIDE

Synonym(s):1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyran;Hexamethylindanopyran;HHCB

CAS NO.：1222-05-5
Empirical Formula: C18H26O
Molecular Weight: 258.4
MDL number: MFCD00072199
EINECS: 214-946-9
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-10 18:36:46

What is GALAXOLIDE?

Description

Galaxolide is a synthetic polycyclic musk used in perfumes and other personal care products. However, it and other polycyclic musks accumulate in tissues and may break down the body''s defenses against toxic substances. Galaxolide and other fragrance additives have been found in tissues in fish taken from US and German waterways.

Chemical properties

Clear Colourless to Pale Yellow Oil

Chemical properties

4,6,6,7,8,8-Hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]benzopyran is a viscous liquid with a musk-like odor. It is one of the most frequently used synthetic, artificial musk fragrances.The starting material for its synthesis is 1,1,2,3,3-pentamethylindane, which is prepared by cycloaddition of tert-amylene to α-methylstyrene. The pentamethylindane is hydroxyalkylated with propylene oxide in a Friedel–Crafts reaction using aluminum chloride as a catalyst (analogous to the synthesis of phenylethyl alcohol from benzene and ethylene oxide . Ring closure of the resulting 1,1,2,3,3-pentamethyl-5-(β-hydroxyisopropyl)indane is accomplished with paraformaldehyde and a lower aliphatic alcohol via the acetal or with paraformaldehyde and a carboxylic acid anhydride via the acylate.
The commercial product is diluted with solvents (e.g., diethyl phthalate, isopropyl myristate, benzyl benzoate) to make it less viscous. It is alkali-stable and does not discolor in light. Therefore, it is a popular ingredient of perfume compositions for soaps, detergents, and cosmetics and is used in large amounts.

The Uses of GALAXOLIDE

Galaxolide is a polycyclic musk (PCM) used as a fragrance ingredient in perfumes, soaps, cosmetics and detergents.

Definition

ChEBI: An organic heterotricyclic compound that is 1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene substituted by methyl groups at positions 4, 6, 6, 7, 8 and 8 respectively. It is a synthetic musk used as a fragrance in cosmetics.

General Description

1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran is an isochromone with a strong musk odor, commonly used in fragrances.

Flammability and Explosibility

Not classified

Trade name

Galaxolide® (IFF), Astromusk (Agan),Musk YingHai (YingHai).

Properties of GALAXOLIDE

Melting point:	57-58°
Boiling point:	304 °C(lit.)
Density	1.044 g/mL at 25 °C(lit.)
vapor pressure	0.073Pa at 25℃
refractive index	n20/D 1.5215(lit.)
Flash point:	>230 °F
storage temp.	Sealed in dry,Room Temperature
form	clear liquid
color	Colorless to Light yellow
Odor	at 100.00 %. strong diffusive sweet floral musk
Water Solubility	1.65mg/L at 25℃
CAS DataBase Reference	1222-05-5(CAS DataBase Reference)
EPA Substance Registry System	1,3,4,6,7,8-Hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2-benzopyran (1222-05-5)

Safety information for GALAXOLIDE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H315:Skin corrosion/irritation H317:Sensitisation, Skin H320:Serious eye damage/eye irritation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P272:Contaminated work clothing should not be allowed out of the workplace. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P391:Collect spillage. Hazardous to the aquatic environment P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..…