G-744

CAS NO.：1346669-54-2
Empirical Formula: C29H29N5O3S
Molecular Weight: 527.64
MDL number: MFCD31556562
Update Date: 2026-04-24 14:59:05

What is G-744?

Description

G-744 is a highly potent, selective for Btk inhibitor. G-774 is metabolically stable, well tolerated, and efficacious in an animal model of arthritis. G-744 prevents cellular functions in murine B-cells such as B-cell receptor (BCR)-mediated CD86 induction with an EC50 of 64nM. G-744 also inhibited BCR-stimulated B-cell proliferation in human B-cells (EC50 = 22 nM). In human monocytes, production of the inflammatory cytokine TNFα following activation with immune complexes was abrogated by G-744 (EC50 = 33 nM). In human whole blood, G-744 demonstrated potent inhibition of BCR-stimulated CD69 expression on Bcells with an EC50 of 87 nM.

Properties of G-744

Boiling point:	820.6±65.0 °C(Predicted)
Density	1.382±0.06 g/cm3(Predicted)
pka	13.99±0.10(Predicted)

Safety information for G-744

Computed Descriptors for G-744

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