FURIN INHIBITOR II
Synonym(s):Hexa-D-arginine amide
- CAS NO.：673202-67-0
- Empirical Formula: C36H75N25O6
- Molecular Weight: 954.14
- MDL number: MFCD04974168
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 05:15:43
What is FURIN INHIBITOR II?
The Uses of FURIN INHIBITOR II
Furin Inhibitor II has been used as a furin inhibitor:
- to study its effects on transforming growth factor β1 (TGF-β1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG).
- to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells.
- in furin cleavage assay.
General Description
Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family. It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes.
Biochem/physiol Actions
Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein?4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteases?and pro-β-nerve growth (pro-β-NGF) factor. Furin is also involved in cleaving transforming growth factor β1 (TGF-β1).
Storage
Store at -20°C
Properties of FURIN INHIBITOR II
| Density | 1.59±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | H2O : 50 mg/mL (52.40 mM; Need ultrasonic)DMSO : 5 mg/mL (5.24 mM; Need ultrasonic) |
| pka | 13.24±0.46(Predicted) |
| form | lyophilized |
| color | White to off-white |
| Water Solubility | Soluble to 2 mg/ml in water |
Safety information for FURIN INHIBITOR II
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for FURIN INHIBITOR II
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