fomivirsen

CAS NO.：160369-77-7
Empirical Formula: C204H243N63Na20O114P20S20
Molecular Weight: 7122.03654
MDL number: MFCD09838480
Update Date: 2025-06-18 16:39:23

What is fomivirsen?

Description

Fomivirsen Sodium was launched as Vitravene in the US and is indicated for the local treatment of cytomegalovirus (CMV)-induced retinitis in AIDS patients. It consists of a phosphorothioate oligonucleotide (PS) comprised of a sequence of 21 nucleotides. Fomivirsen is synthesized using solid-phase phosphoramidite chemistry. Fomivirsen inhibits human CMV replication by a antisense mechanism : it targets an immediate early mRNA of cytomegalovirus, inhibiting the expression of two regulatory proteins. Fomivirsen was the most advanced first-generation PS drug candidate in human clinical trials and was the first agent based on antisense technology to reach the market. In normal human dermal fibroblast cells, Fomivirsen inhibited AD169 human CMV replication by more than 90%, at a concentration of 5μM ; it showed greater hCMV replication inhibitor properties than ganciclovir in several experimental models.

Originator

Isis Pharmaceuticals (US)

brand name

Vitravene

Properties of fomivirsen

storage temp.	Store at -20°C
form	Solid
color	White to off-white

Safety information for fomivirsen

Computed Descriptors for fomivirsen

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