Fmoc-S-Trityl-L-penicillamine

Synonym(s):Fmoc-α, α-dimethyl-Cys(Trt)-OH,Fmoc-S-trityl-L-penicillamine;Fmoc-β,β-dimethyl-Cys(Trt)-OH;Fmoc-S-trityl-L-penicillamine;Fmoc-Pen(Trt)-OH

CAS NO.：201531-88-6
Empirical Formula: C39H35NO4S
Molecular Weight: 613.76
MDL number: MFCD00237388
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-04 16:04:00

Fmoc-S-Trityl-L-penicillamine Structural

What is Fmoc-S-Trityl-L-penicillamine?

Description

Fmoc-S-trityl-L-penicillamine is a coordination compound that contains a thiolate and amide group. It has been used as a model system for studying the interaction between proteins and metal ions, with the cyclic structure mimicking the active site of enzymes. The coordination of Fmoc-S-trityl-L-penicillamine to proteins is affected by trypsin, an enzyme that cleaves peptides at carboxyl side chains. Trypsin can also lead to dehydration of Fmoc-S-trityl-L-penicillamine, forming an eliminations product. This compound also reacts with lysine residues in proteins, resulting in an alkene byproduct that can be removed by hydrogenation.

Chemical properties

White to off-white powder

The Uses of Fmoc-S-Trityl-L-penicillamine

Fmoc-s-trityl-l-penicillamine is a new peptidomimetic furin inhibitors with potent anti-infectious activity.

What are the applications of Application

Fmoc-Pen(Trt)-OH is an Fmoc protected amino acid derivative

Properties of Fmoc-S-Trityl-L-penicillamine

Boiling point:	768.8±60.0 °C(Predicted)
alpha	33 º (c=1 in methanol)
Density	1.242±0.06 g/cm3(Predicted)
storage temp.	Store at -15°C to -25°C.
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
pka	3.70±0.10(Predicted)
optical activity	[α]/D +33±2°, c = 1 in methanol
CAS DataBase Reference	201531-88-6(CAS DataBase Reference)