FMOC-O-tert-Butyl-L-serine
Synonym(s):Fmoc-O-tert-butyl-L -serine;Fmoc-Ser(tBu)-OH;N-α-Fmoc-O-t.-butyl-L-serine
- CAS NO.：71989-33-8
- Empirical Formula: C22H25NO5
- Molecular Weight: 383.44
- MDL number: MFCD00037127
- EINECS: 276-260-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-16 10:24:55
What is FMOC-O-tert-Butyl-L-serine?
Chemical properties
white to light yellow crystal powde
The Uses of FMOC-O-tert-Butyl-L-serine
Fmoc-Ser(tBu)-OH is an N-terminal protected reagent used in the peptide synthesis. Some of the reported examples are:
- Total synthesis of an antibiotic, daptomycin, by cyclization via a chemoselective serine ligation.
- Preparation of MUC1, a T-cell helper peptide, using iterative pentafluorophenyl ester-mediated fragment condensations.
- Linear solid-phase peptide synthesis of ubiquitin and diubiquitin.
General Description
The product number for this product was previously 04-12-1033.
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Properties of FMOC-O-tert-Butyl-L-serine
| Melting point: | 130.5-135.5 °C(lit.) |
| Boiling point: | 510.36°C (rough estimate) |
| alpha | 25 º (c=1,EtOAc 24 ºC) |
| Density | 1.2369 (rough estimate) |
| refractive index | 24 ° (C=1, AcOEt) |
| storage temp. | 2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| pka | 3.44±0.10(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| optical activity | [α]20/D +25.5±1°, c = 1% in ethyl acetate |
| BRN | 3632013 |
| InChI | InChI=1S/C22H25NO5/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/t19-/m0/s1 |
| CAS DataBase Reference | 71989-33-8(CAS DataBase Reference) |
Safety information for FMOC-O-tert-Butyl-L-serine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for FMOC-O-tert-Butyl-L-serine
| InChIKey | REITVGIIZHFVGU-IBGZPJMESA-N |
| SMILES | C(O)(=O)[C@H](COC(C)(C)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O |
FMOC-O-tert-Butyl-L-serine manufacturer
JSK Chemicals
2Y
Phone:+91-9879767984
Whatsapp: +91-9879767970
product: 71989-33-8 N-Fmoc-O-tert-butyl-L-serine, 98% 99%
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