Fmoc-L-Photo-Leucine

Synonym(s):(S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-3-(3-methyl-3H-diazirin-3-yl)propanoic acid;(S)-2-(Fmoc-amino)-3-(3H-diazirin-3-yl)butanoic acid;Photo-crosslinking amino acid;Photo-Leu;Photoprobe building block

CAS NO.：1360651-24-6
Empirical Formula: C20H19N3O4
Molecular Weight: 365.39
MDL number: MFCD31380715
Update Date: 2026-04-24 14:58:42

What is Fmoc-L-Photo-Leucine?

The Uses of Fmoc-L-Photo-Leucine

Fmoc-L-Photo-Leucine is a diazirine-containing, Fmoc-protected leucine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (～360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907278.

Properties of Fmoc-L-Photo-Leucine

Density	1.41±0.1 g/cm3(Predicted)
storage temp.	2-8°C
pka	3.67±0.10(Predicted)
color	White to off-white

Safety information for Fmoc-L-Photo-Leucine

Computed Descriptors for Fmoc-L-Photo-Leucine

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