Fluoroacetonitrile
- CAS NO.：503-20-8
- Empirical Formula: C2H2FN
- Molecular Weight: 59.04
- MDL number: MFCD00009969
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:12:19
What is Fluoroacetonitrile?
The Uses of Fluoroacetonitrile
Fluoroacetonitrile is a water disinfectant byproduct that showed weak inhibition of rat hepatic glutathione S-transferases in vitro. Fluoroacetonitrile is also a reagent in the preparation of the PAD4 inhibitor F-Amidine.
The Uses of Fluoroacetonitrile
Fluoroacetonitrile has been used in preparation of:
- 2-fluoromethyl-4,4,6-trimethyl-1,3-oxazine
- α-fluorinated acetophenone
- 2-amino-2-fluoromethyl-3-pentenenitrile, a key intermediate in the synthesis of 2,5-diamino-2-fluoromethyl-3(E)-pentenoic acid
What are the applications of Application
Fluoroacetonitrile is a fluorinated building block
Synthesis Reference(s)
Journal of Medicinal Chemistry, 26, p. 1551, 1983 DOI: 10.1021/jm00365a002
Properties of Fluoroacetonitrile
| Melting point: | -13 °C |
| Boiling point: | 79-80 °C (lit.) |
| Density | 1.061 g/mL at 25 °C (lit.) |
| refractive index | 1.333 |
| Flash point: | 7°F |
| Water Solubility | Slightly soluble in water |
| form | clear liquid |
| color | Colorless to Almost colorless |
| CAS DataBase Reference | 503-20-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Fluoroacetonitrile(503-20-8) |
Safety information for Fluoroacetonitrile
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Fluoroacetonitrile
New Products
2-(3-Methyl-1,2,4-oxadiazol-5-yl)acetic acid (as potassium salt) 2-fluoro-4-iodoaniline 4-Iodo-3,5-dimethylbenzonitrile Atorvastatin amide impurity/Atorvastatin EP Impurity F(Calcium Salt) Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A (4-Fluoro-2-methoxy-5-nitro- phenyl)-[4- (1-methyl-1H- indol-3- yl)-pyrimidin-2-yl]- amine 6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole tert-butyl 4-(6-((7-cyclo pentyl -6-(dimethyl carbamoyl) -7H-pyrrolo [2,3-d]pyrimidin-2-yl) amino)pyridin-3-yl) piperazine-1-carboxylate 2-Fluoro-4-nitrotoluene 1-(2-amino-5-hydroxy phenyl)propan-1-one (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3- amine 3-(Dimethylamino)benzoic acid 2-Amino-5-chloropyridine 4-(Methylamino)-3-nitrobenzoic Acid 5-Chloro-2-Nitroaniline 3,5-dibenzyloxy Acetophenone 2,4-Diamino-6-hydroxypyrimidine 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy BenzylcyanideRelated products of tetrahydrofuran
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