Fluorinated VHL Spy Molecule 2

Synonym(s):(2S,4R)-N-(4-bromobenzyl)-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide;VHL reporter ligand

CAS NO.：2290526-27-9
Empirical Formula: C14H14BrF3N2O3
Molecular Weight: 395.17
MDL number: MFCD32672269
Update Date: 2026-01-13 11:18:20

Fluorinated VHL Spy Molecule 2 Structural

What is Fluorinated VHL Spy Molecule 2?

The Uses of Fluorinated VHL Spy Molecule 2

Fluorinated VHL Spy Molecule 2 can be used for the discovery of new von Hippel-Lindau (VHL) binders. Based on VH032 (cat# 901490), this reporter was designed in the lab of Alessio Ciulli to bind the hydroxyproline (Hyp) recognition site of VHL. When used in competition ligand-observed 19F NMR screening experiments, its displacement indicates binding by another molecule. Additional Fluorinated VHL Spy Molecules are available as listings 909459, 909440, and 909416.
The E3 ligase VHL is of growing interest for targeted protein degradation and these spy molecules will facilitate the identification of novel VHL ligands and VHL-based degraders.

Properties of Fluorinated VHL Spy Molecule 2

Boiling point:	624.2±55.0 °C(Predicted)
Density	1.637±0.06 g/cm3(Predicted)
pka	13.62±0.40(Predicted)

Safety information for Fluorinated VHL Spy Molecule 2

Computed Descriptors for Fluorinated VHL Spy Molecule 2

New Products

Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) 2-Bromo-5-hydroxybenzoic acid. 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) 4-Fluorophenylglycine 1-N-Boc-3-(aminoethyl)azetidine Dimedone 1-Boc-3-(cyanomethyl)azetidine N-BOC-piperidine-4-carboxylic acid 1-Benzhydrylazetane-3-carbonitrile 5-Amino-2-Hydroxypyridine 2-Amino-5-Iodopyridine 2-BROMOACETYL BROMIDE-D2 METHANE SULFONIC ACID-D4 PHOSPORIC ACID-D3 85 W% IN D2O DEUTERIUM OXIDE FOR NMR BENZENE-D6 TOLUENE-D3 6-Chloro-pyrimidine-2,4-diamine 3-Oxide 1-Acetyl-4-(4-hydroxyphenyl)piperazine 1-(3-Chlorophenyl)piperazine hydrochloride