Flumethasone 21-pivalate
Synonym(s):6α,9-Difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(2,2-dimethylpropionate);Flumetasone 21-pivalate;NSC 107680
- CAS NO.：2002-29-1
- Empirical Formula: C27H36F2O6
- Molecular Weight: 494.57
- MDL number: MFCD00079287
- EINECS: 217-901-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-04 19:55:51
What is Flumethasone 21-pivalate?
Chemical properties
White or almost white, crystalline powder.
The Uses of Flumethasone 21-pivalate
An anti-inflammatory anti-itching corticosteroid found in topical creams.
The Uses of Flumethasone 21-pivalate
flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a pivalate, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.
What are the applications of Application
Flumethasone pivalate is a GR (glucocorticoid receptor) agonist
Definition
ChEBI: Flumethasone pivalate is a pivalate ester, a glucocorticoid, an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It has a role as an anti-inflammatory drug and an antipruritic drug. It is functionally related to a flumethasone.
brand name
Locorten (Novartis).
Properties of Flumethasone 21-pivalate
| Melting point: | >263°C (dec.) |
| Boiling point: | 600.3±55.0 °C(Predicted) |
| Density | 1.27±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | dioxane: soluble4.0ML, clear, colorless to very faintly yellow (50 mg + 4.0 mL dioxane) |
| form | solid |
| pka | 11.86±0.70(Predicted) |
| color | White to Off-White |
| optical activity | [α]25/D 71.0 to 82.0°, c = 1 in dioxane |
| CAS DataBase Reference | 2002-29-1(CAS DataBase Reference) |
| EPA Substance Registry System | Flumethasone-21-pivalate (2002-29-1) |
Safety information for Flumethasone 21-pivalate
| Signal word | Warning |
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H351:Carcinogenicity |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for Flumethasone 21-pivalate
Flumethasone 21-pivalate manufacturer
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