Flumethasone 21-pivalate

Synonym(s):6α,9-Difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(2,2-dimethylpropionate);Flumetasone 21-pivalate;NSC 107680

CAS NO.：2002-29-1
Empirical Formula: C27H36F2O6
Molecular Weight: 494.57
MDL number: MFCD00079287
EINECS: 217-901-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 02:19:04

What is Flumethasone 21-pivalate?

Chemical properties

White or almost white, crystalline powder.

The Uses of Flumethasone 21-pivalate

An anti-inflammatory anti-itching corticosteroid found in topical creams.

The Uses of Flumethasone 21-pivalate

flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a pivalate, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.

What are the applications of Application

Flumethasone pivalate is a GR (glucocorticoid receptor) agonist

Definition

ChEBI: Flumethasone pivalate is a pivalate ester, a glucocorticoid, an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It has a role as an anti-inflammatory drug and an antipruritic drug. It is functionally related to a flumethasone.

brand name

Locorten (Novartis).

Properties of Flumethasone 21-pivalate

Melting point:	>263°C (dec.)
Boiling point:	600.3±55.0 °C(Predicted)
Density	1.27±0.1 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	dioxane: soluble4.0ML, clear, colorless to very faintly yellow (50 mg + 4.0 mL dioxane)
form	solid
pka	11.86±0.70(Predicted)
color	White to Off-White
optical activity	[α]25/D 71.0 to 82.0°, c = 1 in dioxane
CAS DataBase Reference	2002-29-1(CAS DataBase Reference)
EPA Substance Registry System	Flumethasone-21-pivalate (2002-29-1)

Safety information for Flumethasone 21-pivalate

Signal word	Warning
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H351:Carcinogenicity
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..…