FLT3-IN-4
- CAS NO.：2304799-09-3
- Empirical Formula: C23H25N7O2
- Molecular Weight: 431.49
- MDL number: MFCD32067953
- Update Date: 2026-07-27 17:00:41
What is FLT3-IN-4?
Description
FLT3-IN-4 is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor for treating acute myelogenous leukemia[1].
FLT3-IN-4 (Compound 9u) shows potent inhibitory activities against MV4-11 and Molm-13 cells with IC50 values are 0.089±0.001 nM and 0.022±0.003 nM, respectively[1].
References
[1]. Yuan X, et al. Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia. J Med Chem. 2019 Apr 25;62(8):4158-4173.
Properties of FLT3-IN-4
| Boiling point: | 589.1±50.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 12.68±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
Safety information for FLT3-IN-4
Computed Descriptors for FLT3-IN-4
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